Table 7 Main antimicrobials used in swine for the treatment of enteric colibacillosis: routes of administration, dosages and main pharmacokinetic properties (modified from Burch [37])
From: Swine enteric colibacillosis: diagnosis, therapy and antimicrobial resistance
| Antimicrobial class/compounds | Administration and dosage (mg/kg body weight) | Pharmacokinetic Properties | Administration in enteric colibacillosis | ||
|---|---|---|---|---|---|
| Injection | In water | In feed | |||
| Trimethoprim/sulfonamide | 15 (2.5 + 12.5) | 30 (5 + 25) | 15 (2.5 + 12.5) | Rapidly absorbed from intestine,well distributed in tissues;crosses uninflamed blood–brain barrier | IM and orally |
| Amoxicillin | 7 | 20 | 15–20 | IM and orally | |
| Amoxicillin + Clavulanic acid | 7 + 1,75 | IM | |||
| Ceftiofur | 3 | Poorly absorbed from intestine,relatively poorly distributed intissues; crosses only inflamedblood–brain barrier | IM | ||
| Cefquinome | 1–2 | IM | |||
| Enrofloxacin | 2.5 | Well absorbed and distributed intissues | IM | ||
| Neomycin | 11 | 11 | Poorly absorbed from intestine,relatively poorly distributed intissues | Orally | |
| Apramycin | 7.5–12.5 | 4–8 | Poorly absorbed from intestine,relatively poorly distributed intissues | Orally | |
| Spectinomycin | 10–50 | 1.1–2.2 | Poorly absorbed from intestine,relatively poorly distributed intissues | Orally | |
| Colistin sulphate | 100,000 IU/Kg body weight | 100,000 IU/Kg body weight | Not absorbed from intestine. | Orally | |