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| |
Treatment
|
Day of study
|
|---|
|
3
|
7
|
28
|
83
|
125 (DC-1)
|
132 (DC + 6)
|
|---|
|
IL-10
|
T01
|
ND
|
ND
| | | |
4.8 ± 1.0 (1/5)
|
|
T02
|
ND
|
ND
| | | |
5.2 ± 1.7 (1/8)
|
|
T03
|
ND
|
ND
| | | |
10.1 ± 6.4 (2/8)
|
|
P value
|
T01 vs T02
| | | | | |
NS
|
|
T01 vs T03
| | | | | |
NS
|
|
T02 vs T03
| | | | | |
NS
|
|
IL-8
|
T01
|
ND
|
ND
| | | |
48.1 ± 22.9 (3/5)
|
|
T02
|
ND
|
ND
| | | |
33.8 ± 12.7 (3/8)
|
|
T03
|
ND
|
ND
| | | |
69.6 ± 26.2 (6/8)
|
|
P value
|
T01 vs T02
| | | | | |
NS
|
|
T01 vs T03
| | | | | |
NS
|
|
T02 vs T03
| | | | | |
NS
|
|
IFN-α
|
T01
|
ND
|
1.9 ± 0.0 (1/5)
| | | | |
|
T02
|
9.8 ± 6.1 (10/10)
|
32.8 ± 11.8 (10/10)
| | | | |
|
T03
|
9.5 ± 9.7 (9/10)
|
14.1 ± 9.9 (10/10)
| | | | |
|
TNF-α
|
T01
|
ND
|
ND (1/5)a
|
ND
|
62.7 ± 7.6 (1/5)
|
ND
|
29.1 ± 1.5
|
|
T02
|
ND
|
ND
|
ND
|
ND (1/8)a
|
ND
|
41.9 ± 1.6 (1/8)
|
|
T03
|
ND
|
ND
|
ND
|
ND (2/8)a
|
ND
|
78.2 ± 2.9 (1/8)
|
|
P value
|
T01 vs T02
| | | | | |
NS
|
|
T01 vs T03
| | | | | |
NS
|
|
T02 vs T03
| | | | | |
NS
|
|
IFN-γ
|
T01
| | |
1.6 ± 0.0 (5/5)
|
1.6 ± 0.0 (4/5)
|
0.0 ± 0.0 (3/4)
|
8.1 ± 0.5 (3/4)
|
|
T02
| | |
22.1 ± 1.1 (9/10)
|
80.5 ± 8.2 (8/8)
|
166.5 ± 7.1 (8/8)
|
133.5 ± 5.7 (8/8)
|
|
T03
| | |
51.3 ± 4.1 (8/9)
|
77.2 ± 8.2 (8/8)
|
102.2 ± 4.3 (8/8)
|
155.7 ± 6.6 (8/8)
|
|
P value
|
T01 vs T02
| | | | |
0.0003
|
0.0033
|
|
T01 vs T03
| | | | |
0.0108
|
0.0011
|
|
T02 vs T03
| | | | |
NS
|
NS
|
- aAlthough some pigs had values above the cut-off of the technique, the mean value was below the cut-off
- Results from IL-10, IL-8, IFN-α and TNF-α ELISA tests are expressed as pg/mL of serum. Results from IFN-γ ELISPOT are expressed as number of IFN-γ- secreting cells /5 × 105 PBMC. In brackets, the number of positive animals per treatment and time point. DC day of challenge, ND non-detectable (below limit of detection of the technique), NS non-significant; blank cell indicates not measured
