Table 2 ASFV serological immunodeterminants, indicating those described to be recognized by sera from pigs recovered from ASFV infection (antigenic) or to induce immune responses after in vivo immunization (immunogenic)
From: African swine fever vaccines: a promising work still in progress
| Gene name | Protein | Antigenic | Reference | Immunogenic | Reference |
|---|---|---|---|---|---|
| Structural | |||||
| A104R | Histone-like DNA-binding protein | Yes | [69, 70] | Yes | [71] |
| A137R | P11.5 | – | – | Yes | [72] |
| B438L | p49 | – | – | Yes/Low | [73, 74] |
| B602L | p72 chaperone | Yes | [69, 70] | Yes | [74, 75] |
| B646L | p72, major capsid protein | Yes | [27, 69, 76] | Yes | [71, 72, 77, 78] |
| CP204L | p30 | Yes | [27, 69] | Yes | [38, 71,72,73, 77,78,79] |
| CP2475L | pp220 | – | – | Yes | [72] |
| CP2475L/partial | p37 | – | – | Yes | [71] |
| CP530R | pp62 | Yes | [80] | Yes | [38, 81] |
| CP530R/partial | p35 | – | – | Yes | [37, 78] |
| CP530R/partial | p15 | – | – | Yes | [37, 78] |
| D117L |
Major transmembrane protein p17 | – | – | Yes | [73] |
| E183L | p54 | Yes | [27, 69, 70] | Yes/Low | [37, 71, 73, 77,78,79] |
| EP153R | C-type lectin | – | – | Yes | [73] |
| EP402R | HA/CD2v | Yes | [82] | Yes | [71, 73, 78] |
| K78R | p10, DNA-binding | Yes | [69] | – | – |
| KP177R | p22 | – | – | Yes/Low | [73, 77] |
| E120R | p14.5 | – | – | Low | [73] |
| H108R | Inner envelope | – | – | Low | [73] |
| O61R | p12 | – | – | Yes | [73] |
| Non-structural | |||||
| B119L | 9GL, virus assembly | – | – | Yes | [74] |
| F334L | RNA reductase | Yes | [69] | – | – |
| I215L | Ubiquitin conjugating enzyme | – | – | Yes | [38] |
| K196R | Thymidine kinase | Yes | [69] | – | – |
| L10L | KP177R-related | – | – | Yes | [73] |
| NP419L | DNA ligase | Yes | [69] | – | – |
| Uncharacterized | |||||
| A151R | – | – | – | Yes | [74] |
| C129R | – | – | – | Yes | [38] |
| C44L | – | Yes | [69] | – | – |
| CP312R | – | Yes | [69] | Yes | [78] |
| E184L | – | Yes | [69] | – | – |
| K145R | – | Yes | [69] | – | – |
| K205R | – | Yes | [69, 70, 75] | Yes | [74] |
| M448R | – | – | – | Yes | [38] |
| Multigene families | |||||
| MGF110-4 L | XP124L | – | – | Yes | [38] |
| MGF110-5 L | V82L | – | – | Yes | [38] |