Table 3 ASFV-specific T-cell determinants, indicating those described to be recognized by PBMCs from pigs recovered from ASFV infection (antigenic) and those inducing T-cell responses after in vivo immunization (immunogenic)
From: African swine fever vaccines: a promising work still in progress
| Gene name | Protein | Antigenic | Reference | Immunogenic | Reference |
|---|---|---|---|---|---|
| Structural | |||||
| B602L | p72 chaperone | – | – | Yes | [73] |
| B646L | p72 | Yes | [38, 86] | Yes | [38, 71, 73] |
| CP204L | p30 | Yes | [38, 87] | Yes | [38, 71, 73] |
| CP2475L | pp220 | – | – | Yes | [73] |
| CP530R | pp62 | Yes | [38] | Yes | [38, 71, 73] |
| CP530R/partial | p15 | – | – | Yes | [37] |
| D117L | – | – | – | Low | [73] |
| E183L | p54 | – | – | Yes | [71, 73] |
| E248R | Transmembrane myristoylated protein | Yes | [38] | – | – |
| EP153R | C-type lectin | Yes | [88] | Yes | [73] |
| EP402R | HA/CD2v | Yes | [88] | Yes | [73, 89] |
| H108R | Inner envelope | – | – | Low | [73] |
| I239L | – | Yes | [90] | – | – |
| K78R | p10 | Yes | [38] | No | [38] |
| KP177R | p22 | Yes | [38] | Yes | [73] |
| B438L | p49 | – | – | Yes | [73, 74] |
| E199L | j18L | – | – | Yes | [73] |
| O61R | p12 | – | – | Yes | [73] |
| Non-structural | |||||
| A179L | – | – | – | Low | [73] |
| B119L | 9GL, virus assembly | – | – | Yes | [74] |
| C475L | Poly(A) polymerase | Yes | [38] | – | – |
| C962R | DNA primase | Yes | [38] | – | – |
| DP71L | Protein phosphatase 1 regulator | – | – | Low | [73] |
| E165R | dUTPase | Yes | [38] | Yes | [38] |
| E296R | AP endonuclease | Yes | [38] | – | – |
| F1055L | Helicase | – | – | Yes | [73] |
| F334L | RNA reductase | Yes | [38] | – | – |
| G1211R | DNA polymerase | – | – | Yes | [73] |
| G1340L | VACV A7 early transcription factor large subunit-like | Yes | [86] | Low | [73] |
| H339R | Alpha-NAC binding protein | Yes | [38] | – | – |
| H359L | RNA polymerase subunit 3–11 | Yes | [38] | – | – |
| I215L | Ubiquitin conjugating enzyme | Yes | [38] | Yes | [38] |
| I329L | TLR inhibitor | – | – | Low | [73] |
| NP1450L | RNA polymerase subunit 1 | – | – | Yes | [73] |
| NP419L | DNA ligase | Yes | [38] | Yes | [73] |
| NP868R | mRNA-capping enzyme | Yes | [38] | – | – |
| O174L | DNA polymerase X | Yes | [38] | – | – |
| Multigene families | |||||
| MGF110-1 L | – | Yes | [38] | Yes | [38] |
| MGF110-2 L | – | – | – | Low | [73] |
| MGF110-4 L | XP124L | Yes | [38] | Yes | [38] |
| MGF110-5 L | V82L | Yes | [38] | Yes | [38] |
| MGF300-1 L | J268L | Yes | [38] | Low | [73] |
| MGF300-2R | – | – | – | Low | [73] |
| MGF360-11 L | KP362L | – | – | Yes | [73] |
| MGF360-15R | – | – | – | Low | [73] |
| MGF360-16R | – | Yes | [38] | – | – |
| MGF360-18R | – | – | – | Low | [73] |
| MGF360-1 L | KP360L | – | – | Yes | [73] |
| MGF505-11 L | – | Yes | [38] | – | – |
| MGF505-4R | – | – | – | Yes | [73] |
| MGF505-5R | A498R | Yes | [73] | ||
| Uncharacterized | |||||
| 285 L | – | Yes | [38] | – | – |
| A151R | – | Yes | [38] | Yes | [38] |
| B407L | – | – | – | Low | [73] |
| C129R | – | Yes | [38] | Yes | [38] |
| C257L | – | Yes | [38] | ||
| CP312R | – | Yes | [38] | Yes | [38] |
| CP312R | – | – | – | Yes | [31, 91] |
| D339L | – | – | – | Low | [73] |
| DP238L | – | Yes | [38] | – | – |
| E120R | – | – | . | Low | [73] |
| E146L | – | Yes | [38] | Yes | [38] |
| E184L | – | Yes | [38] | Yes | [38] |
| EP364R | – | – | – | Yes | [73] |
| F317L | – | – | – | Yes | [73] |
| I243L | – | Yes | [38] | – | – |
| I73R | – | Yes | [38] | No | [38] |
| K205R | – | Yes | [38] | Yes | [73, 74] |
| L8L | – | Yes | [38] | – | – |
| L10L | – | Yes | [38] | Low | [38, 73] |
| M1249L | – | Yes | [38] | Low | [73] |
| M448R | – | Yes | [38] | Yes | [38] |
| Complement (183875–184,183) | – | – | – | Low | [73] |