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Trials
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Categories
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Groups
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Animal number
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Vaccinesa
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Vaccination program
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Challengeb/boosterc
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Serum sampling
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I
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SPF
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A
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4
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CSF-E2
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6 and 9 weeks old
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CSFV ALD strain
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0, 4, 7, 12, 17, 25 DPC
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B
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4
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–
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–
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Cohabitation at 4 DPC
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4, 7, 12, 17 DPC
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C
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2
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Placebo
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6 and 9 weeks old
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CSFV ALD strain
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0, 4, 7 DPC
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II
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Sow
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D
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25
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CSF-E2
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−5 and −3 weeks before parturition
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–
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3 days after parturition
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E
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35
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LPC
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Once before insemination
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–
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3 days after parturition
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Piglet
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Fd
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20
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–
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–
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–
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1, 4, 8,12 weeks old
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Ge
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20
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–
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–
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–
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1, 4, 8,12 weeks old
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III
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Pigletd
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H
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6
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CSF-E2
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3 and 6 weeks old
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LPC vaccine
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6, 9, 12, 16, 20 weeks old
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I
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6
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LPC
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3 and 6 weeks old
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LPC vaccine
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6, 9, 12, 16, 20 weeks old
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J
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6
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Placebo
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3 and 6 weeks old
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LPC vaccine
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6, 9, 12, 16, 20 weeks old
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IV
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Pigletd
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K
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10
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CSF-E2
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3 weeks old
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–
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4, 8, 12, 16, 20 weeks old
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L
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10
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LPC
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12 and 15 weeks old
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–
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4, 8, 12, 16, 20 weeks old
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M
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10
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Placebo
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3 weeks old
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–
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4, 8, 12, 16, 20 weeks old
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- aCSF-E2 vaccine, baculovirus-expressed CSF-E2 subunit protein emulsified with water-in-oil (W/O) adjuvant; LPC vaccine, live attenuated CSF vaccine; Placebo, 0.9% saline emulsified with the W/O adjuvant
- bGroups A and C were challenged with 1 × 105 TCID50 CSFV (ALD strain) intramuscularly on the neck behind the ear at 12 weeks old
- cGroup H-J pigs were immunized with one dose of LPC vaccine at 16 weeks old as a booster
- dOffspring from 5 sows in group D with CSF-specific antibody blocking percentage over 85% were assigned to group F (4 piglets per litter)
- eOffspring from 5 sows in group E with CSF-specific antibody blocking percentage over 85% were assigned to group G (4 piglets per litter)
